[HTML][HTML] Mechanistic insights into the efficacy of memantine in treating certain drug addictions

C Montemitro, A Angebrandt, TY Wang… - Progress in Neuro …, 2021 - Elsevier
… was associated with increased subjective effects of alcohol, … Thus, this mechanism can
account for the differential efficacy of … high glutamate in alcohol withdrawal, and moderately high …

Acute and chronic glutamate NMDA antagonist treatment attenuates dopamine D1 antagonist-induced reduction of nicotine self-administration in female rats

S Natarajan, G Abass, L Kim, C Wells… - Pharmacology …, 2024 - Elsevier
… between dopamine D 1 and glutamate NMDA receptor systems in … used for developing new
treatments to aid smoking cessation. … Differential interactions were seen in low and high self-…

Brain Glutamate Dynamics Predict Positive Agency in Healthy Women: Insights from Combined Application of Pharmacological Challenge, Comprehensive Affective …

TL White, MA Gonsalves, AD Harris… - ACS Chemical …, 2024 - ACS Publications
… in the subjective effects of Glu. Several factors contribute. First, females’ larger glutamatergic
… Notably, AMP and MA had similar effects on subjective states in males and females (Table …

Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics

AM Jaster, J González-Maeso - Molecular Psychiatry, 2023 - nature.com
… The commonly reported subjective effects of psychedelics … to receptors allowing for differential
signaling implicated in not … administration of the metabotropic glutamate receptor type 2/3 …

[HTML][HTML] … , crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette after a period of smoking …

HJ Green, OK O'Shea, J Cotter, HL Philpott… - Harm Reduction …, 2024 - Springer
… mood and cigarette smoking urges, in people who smoke after … The hypothesis of the study
was that cognitive performance … e-cigarettes and the combustible cigarette and differentiated

[HTML][HTML] Age-dependent effects of tobacco smoke and nicotine on cognition and the brain: A systematic review of the human and animal literature comparing …

K Colyer-Patel, L Kuhns, A Weidema… - Neuroscience & …, 2023 - Elsevier
… of adolescents are able to quit smoking when adulthood emerges. This … differential impact
of adolescent versus adult repeated and long-term tobacco and nicotine exposure on cognitive

[PDF][PDF] Impact of nicotine on cognition in patients with schizophrenia: A narrative review

V Spasova, S Mehmood, A Minhas, R Azhar, S Anand… - Cureus, 2022 - cureus.com
… Following extended nicotine exposure, this differential sensitivity to desensitization may …
shortage of GABA over glutamate, which could be a key mechanism promoting tobacco use [32]. …

Prefrontal GABA and glutamate levels correlate with impulsivity and cognitive function of prescription opioid addicts: A 1H‐magnetic resonance spectroscopy study

JN Li, XL Liu, L Li - Psychiatry and Clinical Neurosciences, 2020 - Wiley Online Library
… or cigarettes 10 … glutamate detected by PRESS sequence has a good reliability and
reproducibility,51-53 it is still a cause for concern whether glutamate can be completely differentiated

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
… abolishes virtually all of the subjective effects of psilocybin, LSD and DMT in … mechanisms,
the LSD or DOI-induced increase in glutamate release produces a marked net excitatory effect

[HTML][HTML] Cotinine: pharmacologically active metabolite of nicotine and neural mechanisms for its actions

X Tan, K Vrana, ZM Ding - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Cigarette smoking remains to be a leading public health … administration, suggesting differential
involvement of nAChRs in … by alterations in glutamate and cholinergic neurotransmission. …